Coordenador: Renato Sotto-Mayor

 

Estudo de quatro anos de tiotrópio na doença pulmonar obstrutiva crónica (estudo UPLIFT)

A 4-year trial of tiotropium in chronic obstructive pulmonary disease (UPLIFT trial)

 

D Tashkin¹

B Celli¹

S Senn¹

D Burkhart¹

S Kesten¹

S Menjoge¹

M Decramer¹

 

Resumo

Racional

O racional deste estudo baseou-se em que vários estudos prévios mostraram eficácia do tiotrópio em diversos parâmetros funcionais e clínicos, em doentes com DPOC, e nomeadamente na redução do declínio a um ano de tratamento (Anzueto 2005).

 

Texto completo disponível apenas em PDF.

Full text only available in PDF format.

 

Bibliografia

Anthonisen NR, Connett JE, Kiley JP, et al. Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1: the Lung Health Study. JAMA 1994;272:1497-505.        [ Links ]

Tashkin DP, Celli B, Decramer M, et al. Bronchodilator responsiveness in patients with COPD. Eur Respir J 2008;31:742-50.

Anzueto A, Tashkin D, Menjoge S, Kesten S. One–year analysis of longitudinal changes in spirometry in patients with COPD receiving tiotropium. Pulm Pharmacol Ther 2005;18:75-81.

American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. Am Rev Respir Dis 1995; 152:77-120.

Quanjer PH. Standardised lung function testing of the European community for coal and steel. Bull Euro Physiopathol Respir 1983; 19:7-28.

 

João Cardoso

2008-11-26

 

¹ UPLIFT Study Investigators