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Revista Portuguesa de Pneumologia

versão impressa ISSN 0873-2159

Rev Port Pneumol v.14 n.5 Lisboa out. 2008

 

Infecção por Bordetella pertussis com hipertensão pulmonar grave num recém -nascido com boa evolução clínica – Caso clínico

 

 Sérgia Soares 1

Gustavo Rocha 1*

Susana Pissarra 1*

Ana Carriço 2

Inês Azevedo 3*

Joana Sobrinho Simões 4

Hercília Guimarães 1*

 

 

Resumo

Apesar da ampla cobertura vacinal, a infecção por Bordetella pertussis está longe de estar controlada. Os recém -nascidos e lactentes ainda sem imunização completa e filhos de mães com baixos títulos de anticorpos para a Bordetella pertussis são altamente susceptíveis à infecção e têm maior risco de doença grave e morte. A infecção por Bordetella pertussis associada a hipertensão pulmonar no recém -nascido é frequentemente fatal.

Os autores descrevem um caso clínico de doença grave num recém -nascido com insuficiência respiratória aguda e hipertensão pulmonar grave, tratado com sucesso com sildenafil e óxido nítrico inalado.

Palavras -chave: Recém -nascido, oxido nítrico, pertussis, hipertensão pulmonar, sildenafil. 

 

 

Pertussis with severe pulmonary hypertension in a newborn with good outcome – case report

Abstract

In spite of the availability and widespread use of vaccines, pertussis is far from controlled. Newborns and infants too young to be fully vaccinated, born from mothers with low antibody titers to Bordetella pertussis, are highly susceptible to infection and at risk of severe disease and death. Pertussis associated with pulmonary hypertension in the newborn is often fatal.

The authors report a clinical case of severe pertussis-induced respiratory failure associated to severe pulmonary hypertension in a neonate successfully treated with sildenafil and inhaled nitric oxide.

Key-words: Neonate, nitric oxide, pertussis, pulmonary hypertension, sildenafil.

 

 

Texto completo disponível apenas em PDF.

Full text only available in PDF format.

 

 

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1 Division of Neonatology, Department of Pediatrics

2 Division of Pediatric Cardiology, Department of Pediatrics

3 Unit of Pediatric Pulmonology, Department of Pediatrics

4 Molecular Biopathology Laboratory, Department of Clinical Pathology

* Faculty of Medicine of Porto University, Porto, Portugal

Correspondence:

Gustavo Rocha

Serviço de Neonatologia / Departamento de Pediatria Hospital de São João – Piso 2 Alameda Prof. Hernâni Monteiro

4202 – 451 Porto Portugal

Tel: +351 225095816

Fax: +351225512273

E -mail: gusrocha@oninet.pt

 

Recebido para publicação/received for publication: 08.02.22

Aceite para publicação/accepted for publication: 08.05.27