Testes de função pulmonar no transplante de medula óssea: Revisão sistemática

Pulmonary function testing in bone marrow transplantation: A systematic review

 

 

Eliane Viana Mancuso¹

Nilton Alves de Rezende²

 

 

Resumo

As complicações pulmonares constituem causa importante de morbidade e mortalidade em doentes submetidos a transplante de medula óssea. Os testes de função pulmonar são utilizados rotineiramente na avaliação antes e no acompanhamento após o transplante. A revisão sistemática da literatura mostrou que a presença de alterações nos testes de função pulmonar antes do transplante de medula não esteve relacionada com maior incidência de complicações pulmonares pós-transplante. Entretanto, alterações destes testes após o transplante estiveram relacionadas com maior incidência de complicações respiratórias. Desta forma, embora as alterações dos testes de função pulmonar pré-transplante não tenham sido de valor preditivo positivo na detecção precoce de complicações respiratórias pós-transplante, os mesmos podem ser úteis na comparação com os testes realizados após o transplante e devem fazer parte da avaliação de doentes candidatos ao transplante de medula óssea.

Palavras-chave: Transplante de medula óssea, testes de função pulmonar, revisão sistemática.

 

Abstract

The pulmonary function test plays an important role in the management of pulmonary complications after bone marrow transplantation. Although its utility in helping to predict the likelihood of developing post transplant pulmonary complications and mortality is not well established, current data indicate that pre-transplant pulmonary function tests are important as a reference for the interpretation of post transplant pulmonary function tests and for identifying patients at high risk of developing pulmonary complications and/or mortality after bone marrow transplantation.

Key-words: Bone marrow transplantation, respiratory function tests, systematic review.

 

 

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¹ Mestranda do Programa de Pós-Graduação em Clínica Médica da Universidade Federal de Minas Gerais, Brasil.

² Professor Adjunto do Departamento de Clínica Médica da Faculdade de Medicina da Universidade Federal de Minas Gerais, Brasil. Doutor em Medicina.

Pós-Doutorado, Emory University, Atlanta, USA.

Trabalho realizado no Serviço de Pneumologia e Transplante de Medula Óssea do Hospital das Clínicas da Universidade Federal de Minas Gerais, Brasil.

Endereço para correspondência: Professor Nilton Alves de Rezende. Departamento de Clínica Médica, Faculdade de Medicina da UFMG

Al. Alfredo Balena 190

CEP-30130-100

Belo Horizonte, Brasil.

e-mail: narezende@terra.com.br

 

Recebido para publicação/received for publication: 05.10.07

Aceite para publicação/accepted for publication: 06.01.09