Abstract

CARVALHO, Diana et al. Hodgkin’s Lymphoma in Crohn’s Disease Treated with Infliximab. GE Port J Gastroenterol [online]. 2017, vol.24, n.6, pp.279-284. ISSN 2341-4545.  https://doi.org/10.1159/000455180.

Introduction: Lymphoproliferative disorders, particularly non-Hodgkin’s and Hodgkin’s lymphomas, are rare in patients with inflammatory bowel diseases. The use of thiopurines and infection by Epstein-Barr virus are well-known cofactors that can raise its prevalence. Other risk factors such as disease activity and biological treatment are the subject of discussion, without enough data in the literature to confirm a potential association. Methods: We report a case of Hodgkin’s lymphoma in a patient who had been treated with azathioprine and was on long-term monotherapy with infliximab. Conclusions: We stress the importance of recognizing the possible occurrence of a lymphoproliferative disorder in association with anti-tumor necrosis factor-α therapy.

Keywords : Crohn’s disease; Hodgkin’s disease; chemically induced; Infliximab; Lymphoproliferative disorders; Tumor necrosis factor-α.

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