Abstract

TEIXEIRA, Ana Carolina et al. Celiac disease, autoimmune atrophic gastritis and Helicobacter pylori in oral iron therapy resistance anemia. Rev Port Med Geral Fam [online]. 2019, vol.35, n.3, pp.197-202. ISSN 2182-5173.  https://doi.org/10.32385/rpmgf.v35i3.12295.

Objectives: Identify the number of celiac disease (CD), autoimmune atrophic gastritis (AAG) and the Helicobacter pylori (Hp) infection in patients with iron-refractory iron deficiency anemia (RIA). Type of study: Observational, retrospective, longitudinal. Location: Hospital center hematology unit in the north region of Portugal. Population: All first hematology consultations of patients with RIA between 2011 and 2016. Methods: Collection of data using the electronic clinical file (socio-demographic, origin of the consultation request and diagnostic tests data). Microsoft Excel 2016® was used to analyze and process the data. Results: We identified 48 cases of iron-refractory iron deficiency anemia (9.3% of 518 patients with iron deficiency anemia). A complete screening for CD, AAG and the infection by Hp was made for 24 patients. A partial screening (only for one or two of these diseases) was made for 19 patients. In the 43 cases that at least one of the screenings were made, the prevalence of CD was about 4.7%, the prevalence of AAG was 14% and the infection by Hp was 30.2%. We couldn’t evaluate the Hp eradication because it wasn’t confirmed in six of 13 cases identified with this pathology. In the other seven cases, Hp eradication solved anemia in only one patient. Conclusion: We identified a high percentage of patients with iron-refractory iron deficiency anemia that suffer from AAG and infection by Hp, as is referred to in international studies. These findings reinforce the role of these diseases in iron-refractory iron deficiency anemia in the Portuguese population. This work reinforces the need to screen for CD, AAG and Hp infection in iron-refractory iron deficiency anemia.

Keywords : Anemia; iron-deficiency; Celiac disease; Gastritis, atrophic; Helicobacter pylori; Iron-refractory; Iron deficiency anemia.

        · abstract in Portuguese     · text in Portuguese     · Portuguese ( pdf )