Resumo

MINUZZI, Luciéle Guerra; TEIXEIRA, Ana Maria Miranda Botelho  e  FERREIRA, José Pedro. Exercise and mobilization of senescent T lymphocytes: A meta-analysis. Motri. [online]. 2015, vol.11, n.2, pp.174-186. ISSN 1646-107X.  https://doi.org/10.6063/motricidade.3385.

The purpose of this study was to evaluate the hypothesis of increased mobilization of senescent T cells to the peripheral blood induced by exercise. The systematic survey of indexed empirical studies was conducted in PubMed and ScienceDirect databases using the keywords: “exercise”, “exercise-induced mobilization of T lymphocytes”, “exercise-induced mobilization of CD8”, “immune space”, “senescent T-cell mobilization”, “naive T-cell repertoire”, “senescent T-cell repertoire”. The main criterion was the mobilization of senescent T lymphocytes after exercise. After search, 442 studies (PUBMED = 99 studies; ScienceDirect = 343 studies) were found and six met all the criteria for inclusion in the meta- analysis. The studies that met the inclusion criteria were assessed for methodological quality with the PEDro scale. Data were analyzed using Comprehensive Meta-analysis software. The difference between the standard errors of the mean (Std diff in means), the confidence interval (95 % CI), and P and Z scores (Z-value and P-value) were calculated. In conclusion, acute exercise mobilizes a population of CD8+ T-cells exhibiting a senescent phenotype into the peripheral blood compartment. It is possible that this mobilization induces apoptosis of these cells and create a vacant space for the production of naive T cells.

Palavras-chave : Exercise; senescent T cells; immunosenescence; immune space.

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