Resumo

ZAREI, K.  e  LESANI, M.. Partially Oxidized Poly Diphenylamine for Sensitive Electrochemical Determination of Ceftazidime. Port. Electrochim. Acta [online]. 2020, vol.38, n.4, pp.229-241. ISSN 0872-1904.  https://doi.org/10.4152/pea.202004229.

This work reports the development of a glassy carbon electrode (GCE), modified with an oxidized poly diphenylamine/multi-walled carbon nanotubes-ß-cyclodextrin (OPDPA /MWCNT-ß-CD) composite film, for ceftazidime determination. The OPDPA/MWCNT-ß-CD film surface morphology was investigated using field emission scanning electron microscopy (FESEM) and cyclic voltammetry (CV). Ceftazidime was adsorbed onto the OPDPA/MWCNT-ß-CD, at open circuit, for 240 seconds, and then oxidized in acidic media. The electrochemistry of ceftazidime oxidation was investigated using cyclic voltammetry and differential pulse voltammetry (DPV). Under optimum conditions, the peak current linearly increased with ceftazidime concentration, in the range of 5×10^-8 M to 1×10^-5 M. The obtained detection limit was 1.0×10^-9 M. This sensor was employed for ceftazidime determination in the biological and pharmaceutical samples.

Palavras-chave : oxidized poly diphenylamine; multi-walled carbon nanotube; ß-cyclodextrin; ceftazidime; adsorptive differential pulse voltammetry; electropolymerization.

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