SciELO - Scientific Electronic Library Online

 
vol.37 issue6Inhibition of Aluminum Corrosion in 0.1 M Na2CO3 by Mentha pulegiumMild Steel Corrosion Inhibition in a NaCl Solution by Lignin Extract of Chromolaena odorata author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

  • Have no similar articlesSimilars in SciELO

Share


Portugaliae Electrochimica Acta

Print version ISSN 0872-1904

Abstract

GOCLIK, E.; CHRZESCIJANSKA, E.; KUSMIEREK, E.  and  RYNKOWSKI, J.. Electroanalytical and Spectrophotometric Determination of N-acetyl-p-aminophenol in Pharmaceuticals. Port. Electrochim. Acta [online]. 2019, vol.37, n.6, pp.345-357. ISSN 0872-1904.  https://doi.org/10.4152/pea.201906345.

Electrochemical oxidation of N-acetyl-p-aminophenol (AAP) and selected pharmaceutical products containing AAP is described in this study. Investigations were carried out at Pt electrode, with the application of cyclic (CV) and differential pulse (DPV) voltammetry. AAP was irreversibly oxidized in, at least, one electrode step, with potentials lower than the potential at which oxygen evolution started. Electrochemical methods based on voltammetric techniques (DPV and CV) have been developed for AAP determination in commercial pharmaceutical drugs. AAP content in pharmaceuticals was determined on the base of dependences of current intensity (electroanalytical measurements) and absorbance (UV-VIS spectra). The obtained results using both methods were in good agreement. The validation of CV, DPV and spectrophotometric methods is also presented. Spectrophotometric and voltammetric responses linearly increased with increasing AAP concentrations, in the range from 0.2 to 5 mmol L-1, with a correlation coefficient of 0.997 (UV-VIS), 0.999 (CV) and 0.998 (DPV). Both electrochemical methods are simple, reliable and sufficiently accurate and precise for AAP quantification in commercial drug samples (tablets). The analysis took only 5 minutes of manual operation, including Pt electrode pre-treatment.

Keywords : Cyclic voltammetry (CV); differential pulse voltammetry (DPV); N-acetyl-p-aminophenol; pharmaceuticals products; UV-VIS spectrophotometry.

        · text in English     · English ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License