Abstract

LEAL, Rita. The failing renal graft: A new chapter for CKD patients. Port J Nephrol Hypert [online]. 2020, vol.34, n.2, pp.73-75. ISSN 0872-0169.  https://doi.org/10.32932/pjnh.2020.07.069.

Returning to dialysis after kidney transplant loss is one of the most difficult transitions for chronic kidney disease patients and their assistant nephrologists. These patients have an increased mortality rate on dialysis and re-transplantation is often difficult due to human leukocyte antigen sensitization narrowing possible donors. The decision on the right timing to start dialysis, vascular access management, optimal immunosuppression withdrawal, graft nephrectomy impact and re-transplant planning are just some of the issues that need to be addressed. However, the optimal care for kidney transplant patients with a failing renal graft is still undefined. In this article we will address this challenging new chapter that affects a growing number of chronic kidney disease patients, with a special focus on allosensitization and immunosuppression withdrawal.

Keywords : graft nephrectomy; HLA; immunosuppressants; kidney graft loss; sensitization.

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