SciELO - Scientific Electronic Library Online

 
vol.33 issue1Nephrocalcinosis in a portuguese pediatric populationCurrent guidelines in peritoneal dialysis - Part I author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

  • Have no similar articlesSimilars in SciELO

Share


Portuguese Journal of Nephrology & Hypertension

Print version ISSN 0872-0169

Abstract

TRUJILLO, Hernando  and  PRAGA, Manuel. Membranous nephropathy: an update. Port J Nephrol Hypert [online]. 2019, vol.33, n.1, pp.19-27. ISSN 0872-0169.  http://dx.doi.org/10.32932/pjnh.2019.04.006.

Great advances have been made in the pathophysiologic and therapeutic areas of membranous nephropathy in the last years. The description of autoantibodies directed against phospholipase A2 receptor in the glomerulus has confirmed the autoimmune nature of the disease and has changed our diagnostic, classification, and treatment strategies. Rituximab has emerged as a great tool in the therapeutic armamentarium of membranous nephropathy, but a one-size-fits-all approach is far from being the rule. Nowadays, an individualized therapeutic scheme based on clinical and serologic data appears to be the most appropriate method to manage patients with membranous nephropathy. We present a review of the most important aspects published in the literature regarding membranous nephropathy, with an emphasis on the most novel topics with the intention of updating clinicians involved in the management of this disease.

Keywords : glomerulonephritis; nephrotic syndrome; membranous nephropathy; phospholipase A2 receptor (PLA2R); autoimmune diseases.

        · text in English     · English ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License