Abstract

BOLIGNANO, Davide. Renal denervation for resistant hypertension: a glimpse of hope on the horizon?. Port J Nephrol Hypert [online]. 2018, vol.32, n.4, pp.344-350. ISSN 0872-0169.

Renal denervation by a minimally-invasive catheter-based procedure has been extensively studied over the last decade as a powerful tool for treating resistant hypertension, a high-risk condition the clinical management of which remains a major challenge. Initial promising results from uncontrolled pilot studies set the stage for a plethora of larger randomized, sham-controlled trials which, however, had unexpectedly negative findings. Despite this transient setback, positive although weak results from the latest Symplicity Spyral studies and a series of new procedural approaches beyond radiofrequency have rekindled enthusiasm for this procedure. New studies are warranted to fully elucidate, once and for all, the limits and potential of and indications for renal denervation in the treatment of resistant hypertension

Keywords : renal denervation; resistant hypertension; nerve ablation.

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