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Portuguese Journal of Nephrology & Hypertension

versão impressa ISSN 0872-0169


PEREIRA, Tiago Assis et al. Are cranberry capsules effective and safe in preventing urinary tract infections in kidney transplantation? A randomized pilot clinical trial. Port J Nephrol Hypert [online]. 2017, vol.31, n.1, pp.18-24. ISSN 0872-0169.

Introduction: Kidney transplant (KT) recipients are highly susceptible to urinary tract infections (UTIs). Few data are available regarding the effects of cranberry products in KT recipients. Subjects and methods: This was a randomized double-blind study comparing daily treatment with a cranberry capsule versus a placebo capsule for 6 months. The study protocol was conducted in accordance with the Helsinki Declaration and was approved by the local ethics committee. The study group comprised women undergoing KT for over 1 year, and the exclusion criteria included simultaneous antibiotic UTI prophylaxis. The primary endpoint was UTI occurrence, and the secondary endpoints were the time to first UTI, hospitalization, antibiotic resistance, graft function, immunosuppressive dose changes, and side effects. Results: 55 KT women at a single centre were included as follows: 25 were randomized to the cranberry group, and 30 were assigned to the placebo group. During the study period, 16.4% of the participants presented with a UTI. A diagnosis of UTI within the previous year and KT duration, but not cranberry use (p=0.95) were independent predictors of UTI. Discussion: Cranberry capsules appear to be safe in KT women; however, no clinical efficacy of UTI prophylaxis was demonstrated in this well-designed but underpowered study. Further multicentric and longer trial should be performed to determine cranberry clinical efficacy

Palavras-chave : Cranberry; Prophylaxis; Kidney Transplantation; Urinary Tract Infection; Vaccinium macrocarpon.

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