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Portuguese Journal of Nephrology & Hypertension

Print version ISSN 0872-0169


CANDIDO, Cristina et al. An Automated Peritoneal Dialysis regimen is not detrimental to Residual Renal Function. Port J Nephrol Hypert [online]. 2016, vol.30, n.4, pp.277-284. ISSN 0872-0169.

Background Residual Renal Function (RRF) preservation is related to survival in Peritoneal Dialysis (PD) patients. The effect of different PD modalities on RRF is unclear. Objectives: To analyse the evolution of RRF function in patients in PD, maintained with automated peritoneal dialysis (APD) and continuous ambulatory peritoneal dialysis (CAPD), and study other possible factors related to RRF decline. Methods: A single-centre retrospective study with 104 incident PD patients (48 CAPD and 56 APD). Patients with no RRF function at PD beginning were excluded. The mean age was 52.1±16 years, 70% were male and 16% diabetics. Thirteen patients used low glucose degradation product (GDP) solutions and 57 patients were using icodextrin. The use of diuretics, angiotensinconverting enzyme inhibitors and angiotensin II receptor blockers was also analysed. RRF and diuresis were analysed every 3 months and peritoneal transport every 6 months, forl a total of 48 months. The mean follow-up was 29.3±19 months. Results: CAPD patients were older, had higher prevalence of diabetes, used less icodextrin and more low GDP solutions and were followed for a longer time. No significant differences in RRF were observed in either modality in basal or during the follow-up: RRF at 24 months with 3.67±3.5ml/min in CAPD patients and 3.82±2.5ml/min in APD patients; or in diuresis: 883±807ml/day and 1333±905ml/day respectively. Neither group showed significant differences in peritoneal transport parameters over time. The use of icodextrin was related to a higher diuresis preservation at 24 months: 1519±1035ml/day in patients using icodextrin and 767±633ml/day in patients without icodextrin (p=0.01). No differences were found in RRF evolution in either group. Conclusions: We conclude that DP modality does not influence either the RRF function or diuresis outcomes or peritoneal transport parameters. The initial use of icodextrin was related to better diuresis preservation without changes in RRF

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