Abstract

NEIVA, Filipa et al. Severe intracranial hemorrhage secondary To neonatal alloimmune thrombocytopenia HPA-3A. Arq Med [online]. 2012, vol.26, n.1, pp.21-24. ISSN 2183-2447.

Neonatal alloimmune thrombocytopenia is the most frequent cause of severe fetal and neonatal thrombocytopenia. Anti HPA1a, 5b e 15b are responsible for up to 95% cases. Thrombocytopenia is frequently severe and major bleeding can occur. Intracranial hemorrhage (ICH) can occur in up to 10-20% of the cases, and is the most feared complication in both ante and postpartum periods. The authors describe the clinical report of a newboRN that was admitted to the Neonatal Unit in his second day of life with generalized hemorrhagic suffusions associated with thrombocytopenia. He was treated with platelets transfusion and endovenous immunoglobulin. Severe ICH was detected in imaging study. laboratory study confirmed the alloimmune thrombocytopenia (HPA 3a) diagnosis. Althought most of the affected newboRNs present clinical improvement in the first week, those with ICH (2/3) develop permanent neurologic sequelae. In order to reduce the morbility and mortality associated with the condition a multisciplinary approach should be undertaken.

Keywords : neonatal alloimmune thrombocytopenia; intracranial hemorrhage.

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